Src
There are 9 members part of the Src family kinases: c-Src , Yes, Fyn, Fgr, Yrk, Lyn, Blk, Hck, and Lck.[8] The expression of these Src family members are not the same throughout all tissues and cell types. Src, Fyn and Yes are expressed ubiquitously in all cell types while the others are generally found in hematopoietic cells. When src is activated, it promotes survival, angiogenesis, proliferation and invasion pathways. It also regulates angiogenic factors and vascular permeability after focal cerebral ischemia-reperfusion,[16][17] and regulates matrix metalloproteinase-9 activity after intracerebral hemorrhage.
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PD 180970是p210Bcr/Abl 激酶 抑制剂也抑制 c-Src，KIT。
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PD 166285 dihydrochloride是活性的 Src 抑制剂， 也能抑制 FGFR1， PDGFRβ 和 Wee1。
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Lavendustin A是EGFR， p60c-src 抑制剂。
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KB SRC 4是活性选择性 c-Src 抑制剂。
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Dasatinib是一种Src/Abl抑制剂，IC50分别为0.6 nM和0.8 nM。
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