Integrin
Integrins are transmembrane receptors that are the bridges for cell-cell and cell-extracellular matrix (ECM) interactions. When triggered, integrins trigger chemical pathways to the interior (signal transduction). This results in a response (activation of transcription) like the regulation of the cell cycle, cell shape, and/or motility; or new receptors being added to the cell membrane. This allows rapid and flexible responses to events at the cell surface, for example to signal platelets to initiate an interaction with coagulation factors.
Integrins are obligate heterodimers, meaning that they have two different chains: the α (alpha) and β (beta) subunits.
Integrins work alongside other receptors such as cadherins, the immunoglobulin superfamily cell adhesion molecules, selectins and syndecans to mediate cell–cell and cell–matrix interaction. Ligands for integrins include fibronectin, vitronectin, collagen, and laminin.
-
Integrin binding sequence that inhibits integrin receptor function. Decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9. Promotes cell attachment and abrogates apoptosis via the mitochondrial pathway in osteoblasts in vitro.
More
-
Firategrast是口服有效的整合素α4β1/α4β7小分子拮抗剂。
More
-
Tirofiban是一种选择性上颚GPIIb/IIIa拮抗剂，可以抑制血小板聚集，IC50为9nM。
More
-
Cyclo(-RGDfK)是整合素αvβ3高效选择性环肽类抑制剂。
More
-
SB273005 是一种有效的integrin抑制剂，对αvβ3 受体和αvβ5受体的Ki分别为1.2 nM 和 0.3 nM。
More
-
Integrin binding sequence that inhibits integrin receptor function. Decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9. Promotes cell attachment and abrogates apoptosis via the mitochondrial pathway in osteoblasts in vitro.
More
-
Firategrast是口服有效的整合素α4β1/α4β7小分子拮抗剂。
More
-
Tirofiban是一种选择性上颚GPIIb/IIIa拮抗剂，可以抑制血小板聚集，IC50为9nM。
More
-
Cyclo(-RGDfK)是整合素αvβ3高效选择性环肽类抑制剂。
More
-
SB273005 是一种有效的integrin抑制剂，对αvβ3 受体和αvβ5受体的Ki分别为1.2 nM 和 0.3 nM。
More
