PKC
PKC (Protein kinase C) is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins, or a member of this family. PKC enzymes in turn are activated by signals such as increases in the concentration of diacylglycerol (DAG) or calcium ions (Ca2+). Hence PKC enzymes play important roles in several signal transduction cascades.
The PKC family consists of fifteen isozymes in humans. They are divided into three subfamilies, based on their second messenger requirements: conventional (or classical), novel, and atypical.
-
Bisindolylmaleimide I (BMI, GF109203X) is a high selectivity, cell-permeable and ATP-competitive inhibitor of PKC and shows GSK-3 inhibition as well. GF 109203X是一种有效的PKC抑制剂，抑制PKCα，PKCβI，PKCβII和PKCγ，IC50分别为20 nM，17 nM，16nM和20 nM，作用于PKC比作用于EGFR，PDGFR和胰岛素受体选择性高3000倍以上。
More
-
Go6976 is a potent protein kinase C (PKC) inhibitor (IC50 = 7.9 nM), selectively inhibits PKCα, and PKCβ1 (IC50 values are 2.3 and 6.2 nM respectively).
More
-
More
-
Dequalinium Chloride是一种PKC抑制剂，IC50为7-18 μM，同时也是一种选择性蜂毒明肽敏感型钾离子通道阻断剂，IC50为1.1 μM。
More
-
Bisindolylmaleimide I (BMI, GF109203X) is a high selectivity, cell-permeable and ATP-competitive inhibitor of PKC and shows GSK-3 inhibition as well. GF 109203X是一种有效的PKC抑制剂，抑制PKCα，PKCβI，PKCβII和PKCγ，IC50分别为20 nM，17 nM，16nM和20 nM，作用于PKC比作用于EGFR，PDGFR和胰岛素受体选择性高3000倍以上。
More
-
Go6976 is a potent protein kinase C (PKC) inhibitor (IC50 = 7.9 nM), selectively inhibits PKCα, and PKCβ1 (IC50 values are 2.3 and 6.2 nM respectively).
More
-
More
-
Dequalinium Chloride是一种PKC抑制剂，IC50为7-18 μM，同时也是一种选择性蜂毒明肽敏感型钾离子通道阻断剂，IC50为1.1 μM。
More
