TRP Channel
TRP channels (Transient receptor potential channels) are a group of ion channels located mostly on the plasma membrane of numerous animal cell types. There are about 28 TRP channels that share some structural similarity to each other. These are grouped into two broad groups: Group 1 includes TRPC,TRPV,TRPM,TRPN, and TRPA. In group 2, there are TRPP ,and TRPML. Many of these channels mediate a variety of sensations like the sensations of pain, hotness, warmth or coldness, different kinds of tastes, pressure, and vision. TRPs have been seen to have complex multidimensional roles in sensory signaling. Many TRPs function as intracellular calcium release channels.
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PF 06465469是活性的 ITK 抑制剂， 也是抑制 BTK。
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PCI 29732是活性的 BTK 抑制剂。
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Ononetin是TRPM3阻断剂。
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OLDA是活性的， 选择性内源性TRPV1 激动剂。
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MRS 1477是TRPV1 阳性变构的调节剂（positive allosteric modulator）。
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