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TRP Channel


TRP channels (Transient receptor potential channels) are a group of ion channels located mostly on the plasma membrane of numerous animal cell types. There are about 28 TRP channels that share some structural similarity to each other. These are grouped into two broad groups: Group 1 includes TRPC,TRPV,TRPM,TRPN, and TRPA. In group 2, there are TRPP ,and TRPML. Many of these channels mediate a variety of sensations like the sensations of pain, hotness, warmth or coldness, different kinds of tastes, pressure, and vision. TRPs have been seen to have complex multidimensional roles in sensory signaling. Many TRPs function as intracellular calcium release channels.

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    PCI 29732是活性的 BTK 抑制剂。

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  • Ononetin EI2014

    Ononetin是TRPM3阻断剂。

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  • OLDA EI1998

    OLDA是活性的， 选择性内源性TRPV1 激动剂。

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    MRS 1477是TRPV1 阳性变构的调节剂（positive allosteric modulator）。

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    ML SA1是TRPML 通路的激动剂。

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