TRP Channel
TRP channels (Transient receptor potential channels) are a group of ion channels located mostly on the plasma membrane of numerous animal cell types. There are about 28 TRP channels that share some structural similarity to each other. These are grouped into two broad groups: Group 1 includes TRPC,TRPV,TRPM,TRPN, and TRPA. In group 2, there are TRPP ,and TRPML. Many of these channels mediate a variety of sensations like the sensations of pain, hotness, warmth or coldness, different kinds of tastes, pressure, and vision. TRPs have been seen to have complex multidimensional roles in sensory signaling. Many TRPs function as intracellular calcium release channels.
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5'-Iodoresiniferatoxin是活性的， silent TRPV1 拮抗剂。
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4-P-PDOT是MT2 拮抗剂。
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2-Phenylmelatonin是活性的 melatonin 激动剂。
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2-Iodomelatonin是高亲和性 melatonin 激动剂。
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2-APB是IP3 受体 拮抗剂。 也是TRP通道调节剂。
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