TRP Channel
TRP channels (Transient receptor potential channels) are a group of ion channels located mostly on the plasma membrane of numerous animal cell types. There are about 28 TRP channels that share some structural similarity to each other. These are grouped into two broad groups: Group 1 includes TRPC,TRPV,TRPM,TRPN, and TRPA. In group 2, there are TRPP ,and TRPML. Many of these channels mediate a variety of sensations like the sensations of pain, hotness, warmth or coldness, different kinds of tastes, pressure, and vision. TRPs have been seen to have complex multidimensional roles in sensory signaling. Many TRPs function as intracellular calcium release channels.
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A 784168是活性的选择性 TRPV1 拮抗剂。
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A 425619是活性的 TRPV1 拮抗剂。
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9-Phenanthrol是9-Phenanthrol is a selective TRPM4 blocker.。
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6'-Iodoresiniferatoxin是高亲和性 TRPV1 激动剂/部分激动剂。
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6-Chloromelatonin是Melatonin 激动剂。
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