TRP Channel
TRP channels (Transient receptor potential channels) are a group of ion channels located mostly on the plasma membrane of numerous animal cell types. There are about 28 TRP channels that share some structural similarity to each other. These are grouped into two broad groups: Group 1 includes TRPC,TRPV,TRPM,TRPN, and TRPA. In group 2, there are TRPP ,and TRPML. Many of these channels mediate a variety of sensations like the sensations of pain, hotness, warmth or coldness, different kinds of tastes, pressure, and vision. TRPs have been seen to have complex multidimensional roles in sensory signaling. Many TRPs function as intracellular calcium release channels.
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MK6-83是TRPML 离子通道激动剂。
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Melphalan是DNA 烷基化试剂， 具有细胞毒性可作为抗肿瘤药物。
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M8 B hydrochloride是活性的，选择性 TRPM8 通道阻断剂。
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Luzindole是竞争性 melatonin MT1/MT2 拮抗剂。
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LFM-A13是活性选择性 BTK 抑制剂。
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