Sodium Channel
Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's plasma membrane. They are classified according to the trigger that opens the channel for such ions, i.e. either a voltage-change ("Voltage-gated", "voltage-sensitive", or "voltage-dependent" sodium channel also called "VGSCs" or "Nav channel") or a binding of a substance (a ligand) to the channel (ligand-gated sodium channels). In excitable cells such as neurons, myocytes, and certain types of glia, sodium channels are responsible for the rising phase of action potentials.
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Proparacaine HCl is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.
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Flubendazole is an autophagy inducer by targeting Atg4B, used to treat internal parasite and worm infection.
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Cimetidine(Tagamet), a histamine congener, competitively inhibits histamine binding to histamine H2 receptors.
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Rufinamide is a new broad-spectrum AED that is structurally unique.Rufinamide is a triazole derivative,which is approved for adjunctive treatment of seizures associated with LGS in patients aged ≥4 years. The efficacy and safety/tolerability of rufinamide in this setting were established in a phase III.
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ICA 121431是活性选择性 NaV1.3，NaV1.1 通道阻断剂。
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