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SGLT

SGLT are a family of glucose transporter found in the intestinal mucosa (enterocytes) of the small intestine (SGLT1) and the proximal tubule of the nephron (SGLT2 in PCT and SGLT1 in PST). They contribute to renal glucose reabsorption. In the kidneys, 100% of the filtered glucose in the glomerulus has to be reabsorbed along the nephron (98% in PCT, via SGLT2). If the plasma glucose concentration is too high (hyperglycemia), glucose is excreted in urine (glucosuria) because SGLT are saturated with the filtered glucose.

3-MATIDA EI0267

3-MATIDA是活性的，选择性 mGlu1 拮抗剂。
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2-MPPA EI0252

2-MPPA是选择性 glutamate carboxypeptidase II (GCP II) 抑制剂，口服有效。
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(S)-HexylHIBO EI0161

(S)-HexylHIBO是Group I mGlu 拮抗剂。
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(S)-4-Carboxy-3-hydroxyphenylglycine EI0158

(S)-4-Carboxy-3-hydroxyphenylglycine是Group I 拮抗剂/group II 激动剂。
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(S)-3-Hydroxyphenylglycine EI0157

(S)-3-Hydroxyphenylglycine是Group I mGlu 激动剂，活性更好的的对映体之一。
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3-MATIDA EI0267

3-MATIDA是活性的，选择性 mGlu1 拮抗剂。
More
2-MPPA EI0252

2-MPPA是选择性 glutamate carboxypeptidase II (GCP II) 抑制剂，口服有效。
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(S)-HexylHIBO EI0161

(S)-HexylHIBO是Group I mGlu 拮抗剂。
More
(S)-4-Carboxy-3-hydroxyphenylglycine EI0158

(S)-4-Carboxy-3-hydroxyphenylglycine是Group I 拮抗剂/group II 激动剂。
More
(S)-3-Hydroxyphenylglycine EI0157

(S)-3-Hydroxyphenylglycine是Group I mGlu 激动剂，活性更好的的对映体之一。
More
3-MATIDA EI0267

3-MATIDA是活性的，选择性 mGlu1 拮抗剂。
More
2-MPPA EI0252

2-MPPA是选择性 glutamate carboxypeptidase II (GCP II) 抑制剂，口服有效。
More
(S)-HexylHIBO EI0161

(S)-HexylHIBO是Group I mGlu 拮抗剂。
More
(S)-4-Carboxy-3-hydroxyphenylglycine EI0158

(S)-4-Carboxy-3-hydroxyphenylglycine是Group I 拮抗剂/group II 激动剂。
More
(S)-3-Hydroxyphenylglycine EI0157

(S)-3-Hydroxyphenylglycine是Group I mGlu 激动剂，活性更好的的对映体之一。
More

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SGLT

3-MATIDA EI0267

2-MPPA EI0252

(S)-HexylHIBO EI0161

(S)-4-Carboxy-3-hydroxyphenylglycine EI0158

(S)-3-Hydroxyphenylglycine EI0157

3-MATIDA EI0267

2-MPPA EI0252

(S)-HexylHIBO EI0161

(S)-4-Carboxy-3-hydroxyphenylglycine EI0158

(S)-3-Hydroxyphenylglycine EI0157

3-MATIDA EI0267

2-MPPA EI0252

(S)-HexylHIBO EI0161

(S)-4-Carboxy-3-hydroxyphenylglycine EI0158

(S)-3-Hydroxyphenylglycine EI0157