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SGLT


SGLT are a family of glucose transporter found in the intestinal mucosa (enterocytes) of the small intestine (SGLT1) and the proximal tubule of the nephron (SGLT2 in PCT and SGLT1 in PST). They contribute to renal glucose reabsorption. In the kidneys, 100% of the filtered glucose in the glomerulus has to be reabsorbed along the nephron (98% in PCT, via SGLT2). If the plasma glucose concentration is too high (hyperglycemia), glucose is excreted in urine (glucosuria) because SGLT are saturated with the filtered glucose. 

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    SDZ NKT 343是高选择性的人 NK1 拮抗剂。

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    RP 67580是活性的，选择性 NK1 拮抗剂。

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    Ro 64-5229是选择性非竞争性mGlu2拮抗剂。

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    Ro 67-7476是mGlu1的阳性变构的调节剂（positive allosteric modulator）。

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  • SDZ NKT 343 EI2524

    SDZ NKT 343是高选择性的人 NK1 拮抗剂。

    More

  • RP 67580 EI2383

    RP 67580是活性的，选择性 NK1 拮抗剂。

    More

  • Ro 64-5229 EI2368

    Ro 64-5229是选择性非竞争性mGlu2拮抗剂。

    More

  • Ro 67-4853 EI2369

    Ro 67-4853是group I mGlu受体阳性变构的调节剂（Positive allosteric modulator of group I mGlu receptors）。

    More

  • Ro 67-7476 EI2370

    Ro 67-7476是mGlu1的阳性变构的调节剂（positive allosteric modulator）。

    More

  • SDZ NKT 343 EI2524

    SDZ NKT 343是高选择性的人 NK1 拮抗剂。

    More

  • RP 67580 EI2383

    RP 67580是活性的，选择性 NK1 拮抗剂。

    More

  • Ro 64-5229 EI2368

    Ro 64-5229是选择性非竞争性mGlu2拮抗剂。

    More

  • Ro 67-4853 EI2369

    Ro 67-4853是group I mGlu受体阳性变构的调节剂（Positive allosteric modulator of group I mGlu receptors）。

    More

  • Ro 67-7476 EI2370

    Ro 67-7476是mGlu1的阳性变构的调节剂（positive allosteric modulator）。

    More
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