P-gp
P-gp (permeability glycoprotein) is an important protein of the cell membrane that pumps many foreign substances out of cells. It is an ATP-dependent efflux pump with broad substrate specificity. It exists in animals, fungi and bacteria and likely evolved as a defense mechanism against harmful substances. P-gp is a glycoprotein that in humans is encoded by the ABCB1 gene. P-gp is a well-characterized ABC-transporter (which transports a wide variety of substrates across extra- and intracellular membranes) of the MDR/TAP subfamily.
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Furosemide是Na+/2Cl-/K+ (NKCC) symporter 抑制剂。 也是 GABAA的拮抗剂。
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Estropipate是Estrogen 受体激动剂，OATP1B1 抑制剂。
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Endoxifen是活性的抗雌激素剂（ antiestrogen）也是 ERα 配体。
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Elacridar hydrochloride是P-gp 抑制剂。
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Cyclofenil是选择性estrogen受体调节剂 (SERM)。
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Furosemide是Na+/2Cl-/K+ (NKCC) symporter 抑制剂。 也是 GABAA的拮抗剂。
More
-
Estropipate是Estrogen 受体激动剂，OATP1B1 抑制剂。
More
-
Endoxifen是活性的抗雌激素剂（ antiestrogen）也是 ERα 配体。
More
-
Elacridar hydrochloride是P-gp 抑制剂。
More
-
Cyclofenil是选择性estrogen受体调节剂 (SERM)。
More
