P-gp


P-gp (permeability glycoprotein) is an important protein of the cell membrane that pumps many foreign substances out of cells. It is an ATP-dependent efflux pump with broad substrate specificity. It exists in animals, fungi and bacteria and likely evolved as a defense mechanism against harmful substances. P-gp is a glycoprotein that in humans is encoded by the ABCB1 gene. P-gp is a well-characterized ABC-transporter (which transports a wide variety of substrates across extra- and intracellular membranes) of the MDR/TAP subfamily.
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    Picrotoxin是GABAA 受体拮抗剂。

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  • Phenobarbital sodium salt EI2156

    Phenobarbital sodium salt是加强 GABA能活性(GABAergic activity)。。

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  • Phaclofen EI2151

    Phaclofen是适度的选择性 GABAB 拮抗剂。

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  • Pentobarbital sodium salt EI2097

    Pentobarbital sodium salt是Pentobarbital sodium salt enhances GABAergic activity。

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  • Org 20599 EI2021

    Org 20599是阳性变构的调节剂(positive allosteric modulator)且是GABAA 受体的直接激动剂。

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  • Picrotoxin EI2173

    Picrotoxin是GABAA 受体拮抗剂。

    More
  • Phenobarbital sodium salt EI2156

    Phenobarbital sodium salt是加强 GABA能活性(GABAergic activity)。。

    More
  • Phaclofen EI2151

    Phaclofen是适度的选择性 GABAB 拮抗剂。

    More
  • Pentobarbital sodium salt EI2097

    Pentobarbital sodium salt是Pentobarbital sodium salt enhances GABAergic activity。

    More
  • Org 20599 EI2021

    Org 20599是阳性变构的调节剂(positive allosteric modulator)且是GABAA 受体的直接激动剂。

    More
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