NMDA
NMDA (N-Methyl-D-aspartic acid or N-Methyl-D-aspartate) is an amino acid derivative that acts as a specific agonist at the NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Unlike glutamate, NMDA only binds to and regulates the NMDA receptor and has no effect on other glutamate receptors. NMDA is an excitotoxin,this trait has applications in behavioral neuroscience research.
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PF-562271, which is a potent ATP-competitive Pyk2/FAK dual inhibitor, has completed phase I clinical trial and is considered to be a promising drug for patients with solid tumors. PF-562271是一种有效的，ATP竞争性的，可逆的FAK抑制剂，IC50为1.5 nM，作用于Pyk2比作用于FAK选择性低10倍左右，比作用于其他蛋白激酶（除了一些CDKs）选择性高100倍以上。
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Zibotentan (ZD4054)是口服活性的内皮素A（ETA）受体特异性拮抗剂，IC50为21 nM。
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Ifenprodil就是酸盐是NMDA受体拮抗剂，选择性抑制含NR2B亚基受体。
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Sitaxsentan钠盐（IPI 1040; TBC 11251）是内皮素A（ETA）受体拮抗剂。
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Bosentan hydrate (波生坦水合物) 是内皮素-A（ETA）和-B（ETB）受体拮抗剂。
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