GABA Receptor
GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief inhibitory compound in the mature vertebrate central nervous system. GABA receptors influence cognition by coordinating with glutamatergic processes. There are two classes of GABA receptors: GABAA and GABAB. GABAA receptors are ligand-gated ion channels; whereas GABAB receptors are G protein-coupled receptors, also called metabotropic receptors. A subclass of ionotropic GABA receptors, insensitive to typical allosteric modulators of GABAA receptor channels such as benzodiazepines and barbiturates, designated GABAС receptor.
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L-655，708是苯二氮卓类反向激动剂（Benzodiazepine ），对α5-containing GABAA 受体具有选择性。
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J 147是J 147 reduces Aβ40，Aβ42 levels（neuroprotective，neurotrophic compound）。
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Isoguvacine hydrochloride是选择性GABAA激动剂。
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NU7441 (KU-57788)是一种高度有效的，选择性DNA-PK抑制剂，IC50为14 nM，也能抑制PI3K，IC50为5 μM。
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(+)-Bicuculline是一种竞争性GABAA受体拮抗剂，IC50为2 μM，也抑制Ca(2+)激活的钾离子通道。
More
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L-655，708是苯二氮卓类反向激动剂（Benzodiazepine ），对α5-containing GABAA 受体具有选择性。
More
-
J 147是J 147 reduces Aβ40，Aβ42 levels（neuroprotective，neurotrophic compound）。
More
-
Isoguvacine hydrochloride是选择性GABAA激动剂。
More
-
NU7441 (KU-57788)是一种高度有效的，选择性DNA-PK抑制剂，IC50为14 nM，也能抑制PI3K，IC50为5 μM。
More
-
(+)-Bicuculline是一种竞争性GABAA受体拮抗剂，IC50为2 μM，也抑制Ca(2+)激活的钾离子通道。
More
