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CFTR


CFTR (Cystic fibrosis transmembrane conductance regulator) is a membrane protein and chloride channel in vertebrates that is encoded by the CFTR gene. The CFTR gene codes for an ABC transporter-class ion channel protein that conducts chloride and thiocyanate ions across epithelial cell membranes. Mutations of the CFTR gene affecting chloride ion channel function lead to dysregulation of epithelial fluid transport in the lung, pancreas and other organs, resulting in cystic fibrosis. 

  • ETP-46464 EY0495

    ETP-46464是可渗透入细胞的多靶点抑制剂，对mTOR，ATR，DNA-PK，PI3-Kα和ATM的IC50分别为0.6，14，36，170和545 nM。

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  • VE-822 EY0438

    VE-822是高亲和力ATR选择性抑制剂，Ki为0.2 nM，对ATM，DNA-PK和mTOR的Ki为34 nM，>4 uM和>1 uM。

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