ATPase
ATPases(adenylpyrophosphatase, ATP monophosphatase, triphosphatase, SV40 T-antigen, adenosine 5'-triphosphatase, ATP hydrolase, complex V) are a class of enzymes that catalyze the decomposition of ATP into ADP and a free phosphate ion. This dephosphorylation reaction releases energy, which the enzyme (in most cases) harnesses to drive other chemical reactions that would not otherwise occur. This process is widely used in all known forms of life. Transmembrane ATPases import many of the metabolites necessary for cell metabolism and export toxins, wastes, and solutes that can hinder cellular processes.
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Brefeldin A 作用于HCT 116细胞，抑制内酯抗生素和ATPase，作用于protein transport（蛋白转运），IC50为0.2 μM，诱导癌细胞分化和凋亡。
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Maraviroc是一种趋化因子受体CCR5抑制剂，作用于MIP-1α， MIP-1β和RANTES 时，IC50分别为3.3 nM， 7.2 nM和5.2 nM。
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Oligomycin A是一种ATP synthase抑制剂，作用于线粒体膜的耦合作用，抑制氧化磷酸化和ATP依赖性的反应。
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STF-083010是Ire1α新型小分子抑制剂，可抑制Ire1核酸内切酶活性但不影响其激酶活性。
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(-)-Blebbistatin是一种可渗透细胞的抑制剂，作用于非肌球蛋白IIATPase，IC50为2 μM，不抑制肌球蛋白轻链激酶，抑制卵裂沟的缢缩，不干扰有丝分裂或收缩环的组装。
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