E2 enzymes
E2 enzymes (Ubiquitin-conjugating enzymes) perform the second step in the ubiquitination reaction that targets a protein for degradation via the proteasome.The ubiquitination process covalently attaches ubiquitin, a short protein of 76 amino acids, to a lysine residue on the target protein. Once a protein has been tagged with one ubiquitin molecule, additional rounds of ubiquitination form a polyubiquitin chain that is recognized by the proteasome's 19S regulatory particle, triggering the ATP-dependent unfolding of the target protein that allows passage into the proteasome's 20S core particle, where proteases degrade the target into short peptide fragments for recycling by the cell.
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CP 135807是选择性 5-HT1D 激动剂。
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Clozapine是Dopamine 拮抗剂 具有部分 D4 选择性。 也是5-HT2A/2C 拮抗剂。
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CJ 033466是选择性 5-HT4 部分激动剂。
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Citalopram hydrobromide是高活性选择性 5-HT uptake inhibitor（摄取抑制剂）。
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Cisapride是5-HT4 激动剂，可以刺激肠道的Ach释放。
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