E2 enzymes
E2 enzymes (Ubiquitin-conjugating enzymes) perform the second step in the ubiquitination reaction that targets a protein for degradation via the proteasome.The ubiquitination process covalently attaches ubiquitin, a short protein of 76 amino acids, to a lysine residue on the target protein. Once a protein has been tagged with one ubiquitin molecule, additional rounds of ubiquitination form a polyubiquitin chain that is recognized by the proteasome's 19S regulatory particle, triggering the ATP-dependent unfolding of the target protein that allows passage into the proteasome's 20S core particle, where proteases degrade the target into short peptide fragments for recycling by the cell.
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LY 393558是Dual 5-HT1B/1D 拮抗剂，5-HT re-uptake inhibitor（重摄取抑制剂）。
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LY 266097 hydrochloride是选择性 5-HT2B 受体拮抗剂。
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LY 272015 hydrochloride是高亲和性 5-HT2B 拮抗剂， 口服活性。
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LY 310762 hydrochloride是5-HT1D-preferring 拮抗剂。
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LY 215840是5-HT2/5-HT7 拮抗剂。
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