E2 enzymes
E2 enzymes (Ubiquitin-conjugating enzymes) perform the second step in the ubiquitination reaction that targets a protein for degradation via the proteasome.The ubiquitination process covalently attaches ubiquitin, a short protein of 76 amino acids, to a lysine residue on the target protein. Once a protein has been tagged with one ubiquitin molecule, additional rounds of ubiquitination form a polyubiquitin chain that is recognized by the proteasome's 19S regulatory particle, triggering the ATP-dependent unfolding of the target protein that allows passage into the proteasome's 20S core particle, where proteases degrade the target into short peptide fragments for recycling by the cell.
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MDL 72222是5-HT3 拮抗剂。
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MDL 12330A hydrochloride是Adenylyl cyclase 抑制剂， 也是cyclic nucleotide PDE 抑制剂。
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m-Chlorophenylbiguanide hydrochloride是活性的特异性 5-HT3 激动剂。
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LY 334370 hydrochloride是选择性 5-HT1F 激动剂。
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LY 344864 hydrochloride是活性选择性 5-HT1F 激动剂。
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