E2 enzymes
E2 enzymes (Ubiquitin-conjugating enzymes) perform the second step in the ubiquitination reaction that targets a protein for degradation via the proteasome.The ubiquitination process covalently attaches ubiquitin, a short protein of 76 amino acids, to a lysine residue on the target protein. Once a protein has been tagged with one ubiquitin molecule, additional rounds of ubiquitination form a polyubiquitin chain that is recognized by the proteasome's 19S regulatory particle, triggering the ATP-dependent unfolding of the target protein that allows passage into the proteasome's 20S core particle, where proteases degrade the target into short peptide fragments for recycling by the cell.
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Nemonapride是高 活性的 D2样拮抗剂。 也是5-HT1A 激动剂。
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N-Desmethylclozapine是5-HT2C 拮抗剂。
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NBOH-2C-CN hydrochloride是高亲和性， 选择性 5-HT2A 激动剂。
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NAS-181是选择性的 r5-HT1B 拮抗剂。 在体内有活性。。
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NAN-190 hydrobromide是5-HT1A 拮抗剂。
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