E2 enzymes
E2 enzymes (Ubiquitin-conjugating enzymes) perform the second step in the ubiquitination reaction that targets a protein for degradation via the proteasome.The ubiquitination process covalently attaches ubiquitin, a short protein of 76 amino acids, to a lysine residue on the target protein. Once a protein has been tagged with one ubiquitin molecule, additional rounds of ubiquitination form a polyubiquitin chain that is recognized by the proteasome's 19S regulatory particle, triggering the ATP-dependent unfolding of the target protein that allows passage into the proteasome's 20S core particle, where proteases degrade the target into short peptide fragments for recycling by the cell.
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SDZ 21009是β-adrenoceptor 拮抗剂。 也是5-HT1A/1B 拮抗剂。
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SCH 23390 hydrochloride是经典的选择性 D1样拮抗剂， 也是5-HT2C和5-HT1C的激动剂，Kir3的通道阻断剂。
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SB 699551是选择性 5-ht5a 拮抗剂。
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SB 399885 hydrochloride是活性选择性 5-HT6 拮抗剂。
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SB 258719 hydrochloride是选择性 5-HT7 拮抗剂。
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