E2 enzymes
E2 enzymes (Ubiquitin-conjugating enzymes) perform the second step in the ubiquitination reaction that targets a protein for degradation via the proteasome.The ubiquitination process covalently attaches ubiquitin, a short protein of 76 amino acids, to a lysine residue on the target protein. Once a protein has been tagged with one ubiquitin molecule, additional rounds of ubiquitination form a polyubiquitin chain that is recognized by the proteasome's 19S regulatory particle, triggering the ATP-dependent unfolding of the target protein that allows passage into the proteasome's 20S core particle, where proteases degrade the target into short peptide fragments for recycling by the cell.
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BP 554 maleate是选择性 5-HT1A 激动剂。
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BIMU 8是活性的 5-HT4 受体全面激动剂(full agonist)。
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Bicifadine hydrochloride是Noradrenalin， 5-HT，dopamine re-uptake inhibitor (重吸收抑制剂)。
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B-HT 920是D2 受体激动剂。 也是 α2 激动剂，5-HT3 拮抗剂。
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BGC 20-761是高亲和性 5-HT6 拮抗剂。
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