E2 enzymes
E2 enzymes (Ubiquitin-conjugating enzymes) perform the second step in the ubiquitination reaction that targets a protein for degradation via the proteasome.The ubiquitination process covalently attaches ubiquitin, a short protein of 76 amino acids, to a lysine residue on the target protein. Once a protein has been tagged with one ubiquitin molecule, additional rounds of ubiquitination form a polyubiquitin chain that is recognized by the proteasome's 19S regulatory particle, triggering the ATP-dependent unfolding of the target protein that allows passage into the proteasome's 20S core particle, where proteases degrade the target into short peptide fragments for recycling by the cell.
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Cinanserin hydrochloride是选择性 5-HT2 拮抗剂。
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CGS 12066B dimaleate是5-HT1B 激动剂。
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BW 723C86 hydrochloride是5-HT2B 激动剂。
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Buspirone hydrochloride是5-HT1A 部分激动剂。
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BRL 54443是活性的 5-ht1E/F 激动剂。
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