Integrin
Integrins are transmembrane receptors that are the bridges for cell-cell and cell-extracellular matrix (ECM) interactions. When triggered, integrins trigger chemical pathways to the interior (signal transduction). This results in a response (activation of transcription) like the regulation of the cell cycle, cell shape, and/or motility; or new receptors being added to the cell membrane. This allows rapid and flexible responses to events at the cell surface, for example to signal platelets to initiate an interaction with coagulation factors.
Integrins are obligate heterodimers, meaning that they have two different chains: the α (alpha) and β (beta) subunits.
Integrins work alongside other receptors such as cadherins, the immunoglobulin superfamily cell adhesion molecules, selectins and syndecans to mediate cell–cell and cell–matrix interaction. Ligands for integrins include fibronectin, vitronectin, collagen, and laminin.
-
SB273005 是一种有效的integrin抑制剂，对αvβ3 受体和αvβ5受体的Ki分别为1.2 nM 和 0.3 nM。
More
-
A-205804强有效和选择性的抑制E-selectin和ICAM-1的表达， IC50分别为20 nM和25 nM。
More
-
SB273005 是一种有效的integrin抑制剂，对αvβ3 受体和αvβ5受体的Ki分别为1.2 nM 和 0.3 nM。
More
-
A-205804强有效和选择性的抑制E-selectin和ICAM-1的表达， IC50分别为20 nM和25 nM。
More
