FAAH
FAAH (Fatty acid amide hydrolase) is a member of the serine hydrolase family of enzymes. FAAH is an integral membrane hydrolase with a single N-terminal transmembrane domain. In vitro, FAAH has esterase and amidase activity.[8] In vivo, FAAH is the principal catabolic enzyme for a class of bioactive lipids called the fatty acid amides (FAAs). Members of the FAAs include: Anandamide,Other N-acylethanolamines,The sleep-inducing lipid oleamide,The N-acyltaurines.Studies in cells and animals and genetic studies in humans have shown that inhibiting FAAH may be a useful strategy to treat anxiety disorders.
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PDP-EA是FAAH 激动剂。
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Palmitoylethanolamide是选择性 GPR55 激动剂。 FAAH，PAA 的底物。
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Palmitoylisopropylamide是FAAH的抑制剂。
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LY 2183240是新型活性的 anandamide uptake inhibitor（摄取抑制剂）， 抑制 FAAH。
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JZL 195是双效FAAH和MAGL 抑制剂。
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