Cytochromes P450 (CYPs)
Cytochromes P450 (CYPs) are proteins of the superfamily containing heme as a cofactor and, therefore, are hemoproteins. CYPs use a variety of small and large molecules as substrates in enzymatic reactions. They are, in general, the terminal oxidase enzymes in electron transfer chains, broadly categorized as P450-containing systems. The term P450 is derived from the spectrophotometric peak at the wavelength of the absorption maximum of the enzyme (450 nm) when it is in the reduced state and complexed with carbon monoxide.Cytochrome P450, family 3, subfamily A, also known as CYP3A, is a human gene. The CYP3A locus includes all the known members of the 3A subfamily of the cytochrome P450 superfamily of genes. These genes encode monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The CYP3A cluster consists of four genes:CYP3A4,CYP3A5,CYP3A7, and CYP3A43.
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Ozagrel是高选择性的血栓素a2（TXA2）合成酶抑制剂。
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Disulfiram是氨基甲酸酯衍生物，可作用于多巴胺-β-羟化酶。
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Abiraterone Acetate是Abiraterone的醋酸盐形式，是一种甾体类细胞色素CYP17抑制剂，IC50为72 nM。
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