Carbonic Anhydrase
The carbonic anhydrases form a family of enzymes that catalyze the rapid interconversion of carbon dioxide and water to bicarbonate and protons (or vice versa), a reversible reaction that occurs relatively slowly in the absence of a catalyst. The active site of most carbonic anhydrases contains a zinc ion; they are therefore classified as metalloenzymes. One of the functions of the enzyme in animals is to interconvert carbon dioxide and bicarbonate to maintain acid-base balance in blood and other tissues, and to help transport carbon dioxide out of tissues.
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Acetazolamide是一种碳酸酐酶（CA）有效抑制剂。
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U-104是一种有效的碳酸酐酶(CA)抑制剂，作用于CA IX和CA XII，Ki分别为45.1 nM和4.5 nM，对CA I和CA II抑制活性弱。
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Topiramate 是镇痉化合物，能拮抗GluR5受体，还可作为GABA受体介导的电流阳性变构调节剂。
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