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MEK


MEK (Mitogen-activated protein kinase kinase,MAP2K,MAPKK) ) is a kinase enzyme which phosphorylates mitogen-activated protein kinase (MAPK). MEK is a member of the MAPK signaling cascade that is activated in melanoma. When MEK is inhibited, cell proliferation is blocked and apoptosis (controlled cell death) is induced. The activators of p38 (MKK3 and MKK6), JNK (MKK4 and MKK7), and ERK (MEK1 and MEK2) define independent MAP kinase signal transduction pathways.

  • TAK-733 EY0829

    TAK-733是MEK变构抑制剂，对MEK1的IC50为3.2 nM，而对Abl1，AKT3，c-RAF，CamK1，CDK2和c-Met则无活性。

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  • Cobimetinib EY0598

    Cobimetinib是MEK1/2高选择性抑制剂。

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