ERKs
ERKs (extracellular signal–regulated kinases ) or classical MAP kinases are widely expressed protein kinase intracellular signalling molecules that are involved in functions including the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells. Many different stimuli, including growth factors, cytokines, virus infection, ligands for heterotrimeric G protein-coupled receptors, transforming agents, and carcinogens, activate the ERK pathway.
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GDC-0994 is a potent, orally available ERK inhibitor with IC50 1.1 nM and 0.3 nM, respectively.
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FR 180204 是一种ATP-竞争性的选择性的ERK抑制剂，其作用于ERK1 和 ERK2的Ki分别为0.31 μM 和 0.14 μM。
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VRT752271是ERK蛋白激酶抑制剂。
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GDC-0994 is a potent, orally available ERK inhibitor with IC50 1.1 nM and 0.3 nM, respectively.
More
-
FR 180204 是一种ATP-竞争性的选择性的ERK抑制剂，其作用于ERK1 和 ERK2的Ki分别为0.31 μM 和 0.14 μM。
More
-
VRT752271是ERK蛋白激酶抑制剂。
More
