S1P Receptor
The sphingosine-1-phosphate receptors are a class of G protein-coupled receptors that are targets of the lipid signalling molecule Sphingosine-1-phosphate (S1P). They are divided into five subtypes: S1PR1, S1PR2, S1PR3, S1PR4 and S1PR5. The sphingosine-1-phosphate receptors regulate fundamental biological processes such as cell proliferation, angiogenesis, migration, cytoskeleton organization, endothelial cell chemotaxis, immune cell trafficking and mitogenesis. Sphingosine-1-phosphate receptors are also involved in immune-modulation and directly involved in suppression of innate immune responses from T cells.
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TC-SP 14是活性的S1P1受体激动剂。
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TC-G 1006是活性的，选择性 sphingosine-1-phosphate receptor 1 (S1P1) 激动剂。
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SEW 2871是具有细胞膜通透性的选择性 S1P1 受体激动剂。
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RP 001 hydrochloride是活性的 S1P1 激动剂。
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JTE 013是S1P2 受体拮抗剂。
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