P2Y Receptor
P2Y receptors are a family of purinergic G protein-coupled receptors, stimulated by nucleotides such as ATP, ADP, UTP, UDP and UDP-glucose. To date, 8 P2Y receptors have been cloned in humans: P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13 and P2Y14. P2Y receptors are present in almost all human tissues where they exert various biological functions based on their G-protein coupling.
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MRS 2690是活性的 P2Y14 激动剂。
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MRS 2693 trisodium salt是选择性 P2Y6 激动剂。
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MRS 2768 tetrasodium salt是选择性 P2Y2 激动剂。
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Ticagrelor是第一个结合可逆的口服P2Y12受体拮抗剂，Ki为2 nM，还能抑制CYP2C9，IC50为10.5 μM。
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S-(+)-Clopidogrel hydrogen sulfate是clopidogrel的S型对映异构体，是P2Y12受体抑制剂。
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MRS 2690是活性的 P2Y14 激动剂。
More
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MRS 2693 trisodium salt是选择性 P2Y6 激动剂。
More
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MRS 2768 tetrasodium salt是选择性 P2Y2 激动剂。
More
-
Ticagrelor是第一个结合可逆的口服P2Y12受体拮抗剂，Ki为2 nM，还能抑制CYP2C9，IC50为10.5 μM。
More
-
S-(+)-Clopidogrel hydrogen sulfate是clopidogrel的S型对映异构体，是P2Y12受体抑制剂。
More
