mGluR
MGluRs are a type of glutamate receptor that are active through an indirect metabotropic process. They are members of the group C family of G-protein-coupled receptors, or GPCRs. Like all glutamate receptors, mGluRs bind with glutamate, an amino acid that functions as an excitatory neurotransmitter. Like other metabotropic receptors, mGluRs have seven transmembrane domains that span the cell membrane. Unlike ionotropic receptors, metabotropic glutamate receptors are not ion channels. Instead, they activate biochemical cascades, leading to the modification of other proteins, as for example ion channels. This can lead to changes in the synapse's excitability, for example by presynaptic inhibition of neurotransmission, or modulation and even induction of postsynaptic responses. Eight different types of mGluRs, labeled mGluR1 to mGluR8 (GRM1 to GRM8), are divided into groups I, II, and III. Receptor types are grouped based on receptor structure and physiological activity. The mGluRs are further divided into subtypes, such as mGluR7a and mGluR7b.
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AZD 9272是活性的，选择性 mGlu5 拮抗剂， 可透过血脑屏障。
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AZD 2066是mGlu5 拮抗剂， 口服有效，。
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AZ 12216052是 mGlu8的阳性变构调节剂。
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AMN 082 dihydrochloride是首个选择性 mGlu7 激动剂。
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ACPT-II是竞争性 mGlu 受体拮抗剂。
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AZD 9272是活性的，选择性 mGlu5 拮抗剂， 可透过血脑屏障。
More
-
AZD 2066是mGlu5 拮抗剂， 口服有效，。
More
-
AZ 12216052是 mGlu8的阳性变构调节剂。
More
-
AMN 082 dihydrochloride是首个选择性 mGlu7 激动剂。
More
-
ACPT-II是竞争性 mGlu 受体拮抗剂。
More
