COX
Cyclooxygenase (COX) is an enzyme (specifically, a family of isozymes) that is responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin. Pharmaceutical inhibition of COX can provide relief from the symptoms of inflammation and pain. Nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin and ibuprofen, exert their effects through inhibition of COX. The two isozymes found in human are called COX-1 and COX-2 in the medical literature.
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Tenoxicam is a good HO. radicals scavenger with an IC50 of 56.7 μM
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Licofelone is a dual COX/LOX inhibitor being considered as a treatment for osteoarthritis.
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Tolfenamic acid is a COX-2 inhibitor with IC50 of 0.2 μM.
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Suprofen(Profenal) is an NSAID.
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Ketorolac (Ketorolac tromethamine) is a non-selective COX inhibitor of COX-1 and COX-2. Ketorolac (tromethamine salt) inhibits both isoforms of Cox in recombinant rat and human enzyme systems. Ketorolac inhibits rat Cox-1 (IC50 of 0.27 μM), rat Cox-2 (IC50 of 2.06 μM), human Cox-1 (IC50 of 1.23 μM) and human Cox-2 (IC50 of 3.50 μM).
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