Cannabinoid Receptor
Cannabinoid receptors, located throughout the body, are part of the Endocannabinoid system which is involved in a variety of physiological processes including appetite, pain-sensation, mood, and memory.
Cannabinoid receptors are of a class of cell membrane receptors under the G protein-coupled receptor superfamily. As is typical of G protein-coupled receptors, the cannabinoid receptors contain seven transmembrane spanning domains. Cannabinoid receptors are activated by three major groups of ligands: endocannabinoids, produced by the mammillary body; plant cannabinoids; and synthetic cannabinoids. There are currently two known subtypes of cannabinoid receptors, termed CB1 and CB2.
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SER 601是活性的， 选择性 CB2 激动剂。
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PSNCBAM-1是CB1 受体阴性变构的调节剂（negative allosteric modulator）。
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PF 514273是活性的，选择性 CB1 拮抗剂。
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Palmitoylethanolamide是选择性 GPR55 激动剂。 FAAH，PAA 的底物。
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O-2050是O-2050 is a putative CB1 silent antagonist; displays mixed activity at CB receptors.。
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