GSK-3
GSK-3 (Glycogen synthase kinase 3) is a serine/threonine protein kinase that mediates the addition of phosphate molecules onto serine and threonine amino acid residues.Phosphorylation of a protein by GSK-3 usually inhibits the activity of its downstream target. GSK-3 is active in a number of central intracellular signaling pathways, including cellular proliferation, migration, glucose regulation, and apoptosis. In mammals GSK-3 is encoded by two known genes, GSK-3 alpha (GSK3A) and GSK-3 beta (GSK3B).
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Tideglusib是不可逆的非ATP竞争性GSK-3β抑制剂，IC50为60 nM。
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SB216763, a potent and selective cell permeable GSK-3 inhibitor, is equally effective at inhibiting human GSK-3α and GSK-3β. SB216763是一种有效的，选择性GSK-3α抑制剂，IC50为34.3 nM，对GSK-3β具有同样的抑制作用。
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TDZD-8是一种非ATP竞争性GSK-3β抑制剂，IC50为2 μM；对CDK1， casein kinase II， PKA和PKC具有最低限度的抑制效果。
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LY2090314是高活性GSK-3抑制剂，对GSK-3α和GSK-3β的IC50分别为1.5 nM和0.9 nM。可提高以铂类为基础的化疗方案的疗效。
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Indirubin是一具有抗炎症和抗癌活性的天然化合物。
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Tideglusib是不可逆的非ATP竞争性GSK-3β抑制剂，IC50为60 nM。
More
-
SB216763, a potent and selective cell permeable GSK-3 inhibitor, is equally effective at inhibiting human GSK-3α and GSK-3β. SB216763是一种有效的，选择性GSK-3α抑制剂，IC50为34.3 nM，对GSK-3β具有同样的抑制作用。
More
-
TDZD-8是一种非ATP竞争性GSK-3β抑制剂，IC50为2 μM；对CDK1， casein kinase II， PKA和PKC具有最低限度的抑制效果。
More
-
LY2090314是高活性GSK-3抑制剂，对GSK-3α和GSK-3β的IC50分别为1.5 nM和0.9 nM。可提高以铂类为基础的化疗方案的疗效。
More
-
Indirubin是一具有抗炎症和抗癌活性的天然化合物。
More
