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TRP Channel


TRP channels (Transient receptor potential channels) are a group of ion channels located mostly on the plasma membrane of numerous animal cell types. There are about 28 TRP channels that share some structural similarity to each other. These are grouped into two broad groups: Group 1 includes TRPC,TRPV,TRPM,TRPN, and TRPA. In group 2, there are TRPP ,and TRPML. Many of these channels mediate a variety of sensations like the sensations of pain, hotness, warmth or coldness, different kinds of tastes, pressure, and vision. TRPs have been seen to have complex multidimensional roles in sensory signaling. Many TRPs function as intracellular calcium release channels.

  • RN 1734 EI2345

    RN 1734是选择性TRPV4拮抗剂。

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  • RN 1747 EI2346

    RN 1747是选择性TRPV4激动剂。

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  • RN 9893 hydrochloride EI2347

    RN 9893 hydrochloride是活性选择性TRPV4拮抗剂。

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  • Pyr3 EI2275

    Pyr3是选择性 TRPC3 阻断剂。

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  • PF 06465469 EI2123

    PF 06465469是活性的 ITK 抑制剂， 也是抑制 BTK。

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