TRP Channel
TRP channels (Transient receptor potential channels) are a group of ion channels located mostly on the plasma membrane of numerous animal cell types. There are about 28 TRP channels that share some structural similarity to each other. These are grouped into two broad groups: Group 1 includes TRPC,TRPV,TRPM,TRPN, and TRPA. In group 2, there are TRPP ,and TRPML. Many of these channels mediate a variety of sensations like the sensations of pain, hotness, warmth or coldness, different kinds of tastes, pressure, and vision. TRPs have been seen to have complex multidimensional roles in sensory signaling. Many TRPs function as intracellular calcium release channels.
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Arachidonyl serotonin是Dual FAAH 抑制剂/TRPV1 拮抗剂。
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AMTB hydrochloride是TRPM8 阻断剂。
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AMG 9810是活性的，选择性， TRPV1的竞争性拮抗剂。
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AMG 21629是活性的，选择性 TRPV1 拮抗剂。
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A 967079是选择性 TRPA1 通道阻断剂。
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