Sodium Channel
Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's plasma membrane. They are classified according to the trigger that opens the channel for such ions, i.e. either a voltage-change ("Voltage-gated", "voltage-sensitive", or "voltage-dependent" sodium channel also called "VGSCs" or "Nav channel") or a binding of a substance (a ligand) to the channel (ligand-gated sodium channels). In excitable cells such as neurons, myocytes, and certain types of glia, sodium channels are responsible for the rising phase of action potentials.
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NAV 26是选择性 Nav1.7 通道阻断剂。
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Mepyramine maleate是选择性 H1 反向激动剂。
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Methimepip dihydrobromide是极度高效的选择性 H3 激动剂。
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LOE 908 hydrochloride是广谱性的离子通道阻断剂， 神经保护活性。
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KC 12291 hydrochloride是口服有效的非典型的 Na+ 通道阻断剂（cardioprotective activity）。
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