Sodium Channel
Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's plasma membrane. They are classified according to the trigger that opens the channel for such ions, i.e. either a voltage-change ("Voltage-gated", "voltage-sensitive", or "voltage-dependent" sodium channel also called "VGSCs" or "Nav channel") or a binding of a substance (a ligand) to the channel (ligand-gated sodium channels). In excitable cells such as neurons, myocytes, and certain types of glia, sodium channels are responsible for the rising phase of action potentials.
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VUF 8430 dihydrobromide是活性高亲和性H4激动剂。
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VUF 10460是选择性 H4 激动剂。
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Veratridine是Veratridine is a voltage-gated Na+ channel opener。
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trans-Triprolidine hydrochloride是高活性的经典H1拮抗剂。
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Tiotidine是活性的， 选择性 H2 拮抗剂。
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