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SGLT


SGLT are a family of glucose transporter found in the intestinal mucosa (enterocytes) of the small intestine (SGLT1) and the proximal tubule of the nephron (SGLT2 in PCT and SGLT1 in PST). They contribute to renal glucose reabsorption. In the kidneys, 100% of the filtered glucose in the glomerulus has to be reabsorbed along the nephron (98% in PCT, via SGLT2). If the plasma glucose concentration is too high (hyperglycemia), glucose is excreted in urine (glucosuria) because SGLT are saturated with the filtered glucose. 

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  • CPPG EI0872

    CPPG是高活性的 group III mGlu 拮抗剂。

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    CPCCOEt是选择性非竞争性 mGlu1 受体拮抗剂。

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  • DCG IV EI0941

    DCG IV是高活性选择性 group II mGlu 激动剂。 也是NMDA 激动剂。

    More

  • DCB EI0939

    DCB是mGlu5的变构的调节剂（allosteric modulator）。

    More

  • CPPHA EI0873

    CPPHA是CPPHA is a Positive allosteric modulator at mGlu1 and mGlu5（阳性变构调节剂）。

    More

  • CPPG EI0872

    CPPG是高活性的 group III mGlu 拮抗剂。

    More

  • CPCCOEt EI0871

    CPCCOEt是选择性非竞争性 mGlu1 受体拮抗剂。

    More

  • DCG IV EI0941

    DCG IV是高活性选择性 group II mGlu 激动剂。 也是NMDA 激动剂。

    More

  • DCB EI0939

    DCB是mGlu5的变构的调节剂（allosteric modulator）。

    More

  • CPPHA EI0873

    CPPHA是CPPHA is a Positive allosteric modulator at mGlu1 and mGlu5（阳性变构调节剂）。

    More

  • CPPG EI0872

    CPPG是高活性的 group III mGlu 拮抗剂。

    More

  • CPCCOEt EI0871

    CPCCOEt是选择性非竞争性 mGlu1 受体拮抗剂。

    More
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