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SGLT


SGLT are a family of glucose transporter found in the intestinal mucosa (enterocytes) of the small intestine (SGLT1) and the proximal tubule of the nephron (SGLT2 in PCT and SGLT1 in PST). They contribute to renal glucose reabsorption. In the kidneys, 100% of the filtered glucose in the glomerulus has to be reabsorbed along the nephron (98% in PCT, via SGLT2). If the plasma glucose concentration is too high (hyperglycemia), glucose is excreted in urine (glucosuria) because SGLT are saturated with the filtered glucose. 

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    LSN 2463359是活性的，选择性mGlu5阳性变构的调节剂（positive allosteric modulator）。

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  • L-Glutamic acid EI1543

    L-Glutamic acid是内源性非选择性激动剂。

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  • L-CCG-l EI1518

    L-CCG-l是活性的 group II mGlu 激动剂。

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  • L-CCG-lll EI1519

    L-CCG-lll是活性的， 竞争性 glutamate uptake inhibitor（摄取抑制剂）。

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  • L-Cysteinesulfinic acid EI1520

    L-Cysteinesulfinic acid是NMDA，mGlu 激动剂。

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  • LSN 2463359 EI1575

    LSN 2463359是活性的，选择性mGlu5阳性变构的调节剂（positive allosteric modulator）。

    More

  • L-Glutamic acid EI1543

    L-Glutamic acid是内源性非选择性激动剂。

    More

  • L-CCG-l EI1518

    L-CCG-l是活性的 group II mGlu 激动剂。

    More

  • L-CCG-lll EI1519

    L-CCG-lll是活性的， 竞争性 glutamate uptake inhibitor（摄取抑制剂）。

    More

  • L-Cysteinesulfinic acid EI1520

    L-Cysteinesulfinic acid是NMDA，mGlu 激动剂。

    More

  • LSN 2463359 EI1575

    LSN 2463359是活性的，选择性mGlu5阳性变构的调节剂（positive allosteric modulator）。

    More

  • L-Glutamic acid EI1543

    L-Glutamic acid是内源性非选择性激动剂。

    More

  • L-CCG-l EI1518

    L-CCG-l是活性的 group II mGlu 激动剂。

    More

  • L-CCG-lll EI1519

    L-CCG-lll是活性的， 竞争性 glutamate uptake inhibitor（摄取抑制剂）。

    More

  • L-Cysteinesulfinic acid EI1520

    L-Cysteinesulfinic acid是NMDA，mGlu 激动剂。

    More
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