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SGLT


SGLT are a family of glucose transporter found in the intestinal mucosa (enterocytes) of the small intestine (SGLT1) and the proximal tubule of the nephron (SGLT2 in PCT and SGLT1 in PST). They contribute to renal glucose reabsorption. In the kidneys, 100% of the filtered glucose in the glomerulus has to be reabsorbed along the nephron (98% in PCT, via SGLT2). If the plasma glucose concentration is too high (hyperglycemia), glucose is excreted in urine (glucosuria) because SGLT are saturated with the filtered glucose. 

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    LY 354740是活性高选择性 group II mGlu 激动剂。

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  • LY 367385 EI1605

    LY 367385是选择性 mGlu1a 拮抗剂。

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  • LY 379268 EI1606

    LY 379268是高选择性 group II mGlu 激动剂。

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  • LY 2389575 hydrochloride EI1590

    LY 2389575 hydrochloride是选择性mGlu3阴性变构调节剂（positive allosteric modulator）。

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  • L-Quisqualic acid EI1572

    L-Quisqualic acid是AMPA/group I mGlu 激动剂。

    More

  • LY 354740 EI1604

    LY 354740是活性高选择性 group II mGlu 激动剂。

    More

  • LY 367385 EI1605

    LY 367385是选择性 mGlu1a 拮抗剂。

    More

  • LY 379268 EI1606

    LY 379268是高选择性 group II mGlu 激动剂。

    More

  • LY 2389575 hydrochloride EI1590

    LY 2389575 hydrochloride是选择性mGlu3阴性变构调节剂（positive allosteric modulator）。

    More

  • L-Quisqualic acid EI1572

    L-Quisqualic acid是AMPA/group I mGlu 激动剂。

    More

  • LY 354740 EI1604

    LY 354740是活性高选择性 group II mGlu 激动剂。

    More

  • LY 367385 EI1605

    LY 367385是选择性 mGlu1a 拮抗剂。

    More

  • LY 379268 EI1606

    LY 379268是高选择性 group II mGlu 激动剂。

    More

  • LY 2389575 hydrochloride EI1590

    LY 2389575 hydrochloride是选择性mGlu3阴性变构调节剂（positive allosteric modulator）。

    More

  • L-Quisqualic acid EI1572

    L-Quisqualic acid是AMPA/group I mGlu 激动剂。

    More
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