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SGLT


SGLT are a family of glucose transporter found in the intestinal mucosa (enterocytes) of the small intestine (SGLT1) and the proximal tubule of the nephron (SGLT2 in PCT and SGLT1 in PST). They contribute to renal glucose reabsorption. In the kidneys, 100% of the filtered glucose in the glomerulus has to be reabsorbed along the nephron (98% in PCT, via SGLT2). If the plasma glucose concentration is too high (hyperglycemia), glucose is excreted in urine (glucosuria) because SGLT are saturated with the filtered glucose. 

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    ML 337是选择性mGlu3阴性变构的调节剂（negative allosteric modulator）。

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    ML 289是选择性mGlu3阴性变构的调节剂（negative allosteric modulator）。

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    LY 456236 hydrochloride是选择性 mGlu1 拮抗剂。

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    LY 487379 hydrochloride是选择性mGlu2的阳性变构的调节剂（positive allosteric modulator）。

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  • LY 341495 EI1601

    LY 341495是高活性的选择性 group II 拮抗剂。

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  • ML 337 EI1721

    ML 337是选择性mGlu3阴性变构的调节剂（negative allosteric modulator）。

    More

  • ML 289 EI1718

    ML 289是选择性mGlu3阴性变构的调节剂（negative allosteric modulator）。

    More

  • LY 456236 hydrochloride EI1610

    LY 456236 hydrochloride是选择性 mGlu1 拮抗剂。

    More

  • LY 487379 hydrochloride EI1611

    LY 487379 hydrochloride是选择性mGlu2的阳性变构的调节剂（positive allosteric modulator）。

    More

  • LY 341495 EI1601

    LY 341495是高活性的选择性 group II 拮抗剂。

    More

  • ML 337 EI1721

    ML 337是选择性mGlu3阴性变构的调节剂（negative allosteric modulator）。

    More

  • ML 289 EI1718

    ML 289是选择性mGlu3阴性变构的调节剂（negative allosteric modulator）。

    More

  • LY 456236 hydrochloride EI1610

    LY 456236 hydrochloride是选择性 mGlu1 拮抗剂。

    More

  • LY 487379 hydrochloride EI1611

    LY 487379 hydrochloride是选择性mGlu2的阳性变构的调节剂（positive allosteric modulator）。

    More

  • LY 341495 EI1601

    LY 341495是高活性的选择性 group II 拮抗剂。

    More
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