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SGLT


SGLT are a family of glucose transporter found in the intestinal mucosa (enterocytes) of the small intestine (SGLT1) and the proximal tubule of the nephron (SGLT2 in PCT and SGLT1 in PST). They contribute to renal glucose reabsorption. In the kidneys, 100% of the filtered glucose in the glomerulus has to be reabsorbed along the nephron (98% in PCT, via SGLT2). If the plasma glucose concentration is too high (hyperglycemia), glucose is excreted in urine (glucosuria) because SGLT are saturated with the filtered glucose. 

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  • Ro 01-6128 EI2348

    Ro 01-6128是mGlu1阳性变构的调节剂（positive allosteric modulator）。

    More

  • PHCCC EI2153

    PHCCC是活性的 group I mGlu 拮抗剂。

    More

  • O-Phospho-L-serine EI2016

    O-Phospho-L-serine是Group III mGlu 激动剂。

    More

  • NPS 2390 EI1934

    NPS 2390是Group I mGlu 拮抗剂。

    More

  • MSPG EI1793

    MSPG是Group II/group III mGlu 拮抗剂。

    More

  • Ro 01-6128 EI2348

    Ro 01-6128是mGlu1阳性变构的调节剂（positive allosteric modulator）。

    More

  • PHCCC EI2153

    PHCCC是活性的 group I mGlu 拮抗剂。

    More

  • O-Phospho-L-serine EI2016

    O-Phospho-L-serine是Group III mGlu 激动剂。

    More

  • NPS 2390 EI1934

    NPS 2390是Group I mGlu 拮抗剂。

    More

  • MSPG EI1793

    MSPG是Group II/group III mGlu 拮抗剂。

    More
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