P-gp
P-gp (permeability glycoprotein) is an important protein of the cell membrane that pumps many foreign substances out of cells. It is an ATP-dependent efflux pump with broad substrate specificity. It exists in animals, fungi and bacteria and likely evolved as a defense mechanism against harmful substances. P-gp is a glycoprotein that in humans is encoded by the ABCB1 gene. P-gp is a well-characterized ABC-transporter (which transports a wide variety of substrates across extra- and intracellular membranes) of the MDR/TAP subfamily.
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ASP3026是高活性ALK抑制剂，IC50为3.5 nM。
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Canagliflozin是高活性hSGLT2选择性抑制剂，IC50为2.2 nM，比对hSGLT1的抑制性强413倍。
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Ethisterone为可作用于前列腺癌的孕激素。
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Bazedoxifene HCl是一种新型非甾类基于吲哚的雌激素受体调节剂(SERM)，靶点有ERα和ERβ，IC50分别为23nM和89nM。
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Medroxyprogesterone醋酸盐是孕酮受体激动剂，是合成的人激素孕酮变体。
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ASP3026是高活性ALK抑制剂，IC50为3.5 nM。
More
-
Canagliflozin是高活性hSGLT2选择性抑制剂，IC50为2.2 nM，比对hSGLT1的抑制性强413倍。
More
-
Ethisterone为可作用于前列腺癌的孕激素。
More
-
Bazedoxifene HCl是一种新型非甾类基于吲哚的雌激素受体调节剂(SERM)，靶点有ERα和ERβ，IC50分别为23nM和89nM。
More
-
Medroxyprogesterone醋酸盐是孕酮受体激动剂，是合成的人激素孕酮变体。
More
