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Gemfibrozil (Lopid) is a compound used to lower lipid levels.
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Ketorolac (Ketorolac tromethamine) is a non-selective COX inhibitor of COX-1 and COX-2. Ketorolac (tromethamine salt) inhibits both isoforms of Cox in recombinant rat and human enzyme systems. Ketorolac inhibits rat Cox-1 (IC50 of 0.27 μM), rat Cox-2 (IC50 of 2.06 μM), human Cox-1 (IC50 of 1.23 μM) and human Cox-2 (IC50 of 3.50 μM).
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Acetaminophen is a inhibitor of Cox-1, Cox-2, and Cox-3 (cyclooxygenase) . Acetaminophen may be selective for Cox-3 (IC50 values are > 1000, > 1000, and 460 μM for murine Cox-1, murine Cox-2, and canine Cox-3, respectively). Acetaminophen is a widely used analgesic and antipyretic agent.
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Etodolac, a member of non steroidal anti-inflammatory drugs (NSAIDs), has a poor aqueous solubility. Etodolac (Lodine) is a COX inhibitor with an IC50 of 53.5 nM.
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Nepafenac is a potent NSAID that rapidly penetrates the eye following topical ocular administration. In the eye, nepafenac is converted to amfenac, which has unique time-dependent inhibitory properties for COX-1 and COX-2.
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