Gardos Channel
Gardos Channel (Potassium intermediate/small conductance calcium-activated channel, subfamily N,KCNN4) is a human gene encoding the KCa3.1 protein. The KCa3.1 protein is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.
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Macbecin I是Hsp90 抑制剂。
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Givinostat (ITF2357)是一种有效的HDAC抑制剂，作用于HDAC2， HDAC1B和HDAC1A时，IC50分别为10 nM， 7.5 nM和16 nM。
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Scriptaid是HDAC抑制剂，相对于H3对乙酰化的H4效果更明显。
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Romidepsin (FK228, Depsipeptide)是一种HDAC1和HDAC2抑制剂，IC50分别为36 nM和47 nM。
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17-DMAG (Alvespimycin) HCl是一种水溶性HSP90抑制剂，IC50为62 nM。
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