CRM1


CRM1 (chromosomal maintenance 1,Exportin 1 (XPO1)) is an eukaryotic protein that mediates the nuclear export of proteins, rRNA, snRNA, and some mRNA. Exportin 1 mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1.
  • NBQX EI1841

    NBQX是活性的 AMPA 拮抗剂。 活性强过CNQX。

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  • Naspm trihydrochloride EI1832

    Naspm trihydrochloride是Ca2+-permeable AMPA 受体拮抗剂。

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  • LY 404187 EI1609

    LY 404187是选择性 AMPA 受体阳性变构的调节剂(positive allosteric modulator)。

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  • L-Quisqualic acid EI1572

    L-Quisqualic acid是AMPA/group I mGlu 激动剂。

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  • IEM 1925 dihydrobromide EI1337

    IEM 1925 dihydrobromide是IEM 1925 dihydrobromide is a voltage- and use-dependent open-channel antagonist of AMPA receptors.。

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