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CRM1


CRM1 (chromosomal maintenance 1,Exportin 1 (XPO1)) is an eukaryotic protein that mediates the nuclear export of proteins, rRNA, snRNA, and some mRNA. Exportin 1 mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1.

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    Diazoxide是AMPA 受体脱敏阻断剂（block desensitization）。

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  • Cyclothiazide EI0900

    Cyclothiazide是AMPA 选择性脱敏抑制剂(desensitization)。

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  • CX 614 EI0892

    CX 614是AMPAkine， AMPA的阳性变构调节剂(Positive Allosteric Modulator)。

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  • CX 546 EI0891

    CX 546是AMPA 受体活性激动剂。

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    CP 465022 hydrochloride是选择性非竞争性 AMPA 拮抗剂。

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