E2 enzymes
E2 enzymes (Ubiquitin-conjugating enzymes) perform the second step in the ubiquitination reaction that targets a protein for degradation via the proteasome.The ubiquitination process covalently attaches ubiquitin, a short protein of 76 amino acids, to a lysine residue on the target protein. Once a protein has been tagged with one ubiquitin molecule, additional rounds of ubiquitination form a polyubiquitin chain that is recognized by the proteasome's 19S regulatory particle, triggering the ATP-dependent unfolding of the target protein that allows passage into the proteasome's 20S core particle, where proteases degrade the target into short peptide fragments for recycling by the cell.
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Cyproheptadine hydrochloride是5-HT2 拮抗剂。
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Cyanopindolol hemifumarate是5-HT1A/1B 拮抗剂。也作为β-adrenergic拮抗剂。
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CP 94253 hydrochloride是活性选择性 5-HT1B 激动剂。
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CP 93129 dihydrochloride是5-HT1B 激动剂。
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CP 809101 hydrochloride是活性选择性 5-HT2C 激动剂。
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